pamojja wrote:francisunderwood wrote:Does anyone know what the best dosage per day of tocotrienols would be?
This article talks about 200 mg/d:
http://www.medscape.com/viewarticle/830034_3, scroll down to the section tocotrienols.
I used nutricology's delta fraction 125mg per cap, damn the just raised the price again.
Thanks so much for that link. After reading it I am going to try and get about 200mg of tocotrienols per day and I think the most cost effective way is by taking 1 delta fraction 125mg and 2 of the doctors best 50mg tocotrienols per day. By my estimate it would give me near 200mg per day of the gamma and delta tocotrienols per day at a cost of $1.05 per day which is not bad. A few quotes below make me think I should take the tocotrienols at night and the tocopherols during the morning. What are your thoughts based on the quotes below?
"The tocotrienol dose is very important, as increased dosing will induce its own metabolism and reduce effectiveness, whereas lower doses are not as effective.[5] Also concomitant intake (less than 12 h) of ?-tocopherol reduces tocotrienol absorption. Increased intake of alpha tocopherol over 20% of total tocopherols may interfere with the lipid-lowering effect."
"Tocotrienols are metabolized by successive ?-oxidation then catalyzed by the CYP450 enzymes 3A4 and CYP4F2.[5] The combination of a statin with ?/? tocotrienols further reduces LDL cholesterol by 10%.[135] The tocotrienols block the adaptive response of upregulation of HMG-CoA reductase secondary to competitive inhibition by the statins.[5,135] Carotid artery stenosis regression has been reported in approximately 30% of subjects given tocotrienols over 18 months. They also slow progression of generalized atherosclerosis.[5,137] The recommended dose is 200 mg of ?? tocotrienol at night with food."